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Funding Opportunities

The following are funding opportunities from the National Institutes of Health related to the Alzheimer's Disease Sequencing Project (ASDP). See the NIH Guide to Grants and Contracts for NIH grant policies, guidelines, and funding opportunities.

PAR-15-356: Limited Competition: Analysis of Data from NIA's Alzheimer's Disease Sequencing Project Follow-Up Study (U01)

Expiration Date: May 8, 2020

The National Institute on Aging invites applications specific to the analysis of genome-wide association studies and whole-genome and related sequencing data generated under PAR-16-406.

PAR-15-356: Major Opportunities for Research in Epidemiology of Alzheimer's DIsease and Cognitive Resilience (R01)

Expiration Date: September 8, 2018

This Funding Opportunity Announcement (FOA) encourages investigator-initiated applications addressing the epidemiology of Alzheimer’s disease (AD) as well as protective factors for cognitive health and resilience. All projects in cognitive epidemiology and genetics/genomics relevant to AD are welcome. NIA especially encourages projects or revisions to projects that propose: augmenting existing longitudinal cohort studies; enabling precision medicine for AD; enhancing the power of multi-ethnic cohort studies; exploring trends in the risk of AD and their explanation via putative risk and protective factors; collecting and sequencing DNA samples from well-characterized cases and controls; electronic archiving of cohort studies; harmonizing complex data sets relevant to AD; and harmonizing dementia assessment to enhance cross-national comparisons.

PAR-17-054: Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors for Alzheimer's Disease and Related Dementias (R01)

Expiration Date: November 6, 2019

This FOA invites applications that will combine multiple cohorts in order to improve statistical power and clarify risk and protective factors for Alzheimer’s disease and related dementias (AD/ADRD).

RFA-AG-17-055: Brain Lymphatic System in Aging and Alzheimer's Disease (R01). See also NOT-AG-16-080: Notice of Change to Funds Available for RFA-AG-17-055 "Brain Lymphatic System in Aging and Alzheimer's Disease (R01)"

Expiration Date: February 10, 2017

The goal of this Funding Opportunity Announcement (FOA) is to support research that will lead to a greater understanding of complex mechanisms by which the brain glymphatic system and meningeal and peripheral lymphatic systems change in normal and pathological brains. This knowledge is critical to determine whether a functional impairment or disruption of these systems may be involved in neurological disorders that are associated with immune system dysfunction, such as Alzheimer’s disease.

 

RFA-AG-17-053: Human Cell Biology of Genetic Variants in Alzheimer's Disease (R01). See also NOT-AG-16-079: Notice of Change to Funds Available for RFA-AG-17-053 "Human Cell Biology of Genetic Variants in Alzheimer's Disease"

Expiration Date: February 11, 2017

The goal of this Finding Opportunity Announcement (FOA) is to establish functional genotype-phenotype relationships of genetic variants, suspected of altering the risk of Alzheimer’s disease (AD), in neural cells using human induced pluripotent stem cells or other human cell reprogramming approaches. The causal linkage of AD-associated genetic variants identified in genome-wide association studies and genome sequencing studies to molecular and biological cell phenotypes in human neural cells is expected to give greater insight into molecular targets contributing to the etiology of AD.

 

RFA-AG-17-050: Role of Peripheral Proteostasis on Brain Aging and on Alzheimer's Disease (R01). See also NOT-AG-16-078: Notice of Change to Funds Available for RFA-AG-17-050 "Role of Peripheral Proteostasis on Brain Aging and on Alzheimer's Disease"

Expiration Date: January 13, 2017

This Funding Opportunity Announcement (FOA) is soliciting research projects that would advance biomedical research on the role of peripheral proteostasis on brain structure and function during aging and in Alzheimer’s disease, facilitating the identification of molecular and cellular markers of normal brain aging and brain aging during pathological conditions.

 

RFA-AG-17-057: Systems Biology Approaches to Alzheimer's Disease Using Non-mammalian Animal Models (R01). See also NOT-AG-16-077: Notice of Change of Funds Available for RFA-AG-17-057

Expiration Date: January 19, 2017

This Funding Opportunity Announcement (FOA) is intended to support discovery of candidate causes or amplifiers of, or protections against, neurodegeneration, and not studies on mechanisms of neurodegeneration which may or may not be specific to neurons and their associated cells.

 

PAR-16-406: Limited Competition: Additional Sequencing for the Alzheimer's Disease Sequencing Project (U01)

Expiration Date: September 8, 2019

This Funding Opportunity Announcement (FOA) invites applications specific to sample acquisition, genome wide association studies, whole genome sequencing, quality control checking, variant calling, and data calling that will support the generation of data for the Alzheimer's Disease Sequencing Project Follow-Up Study.  

 

RFA-AG-17-010: From Association to Function in the Alzheimer’s Disease Post Genomics Era (R01)

Expiration Date: September 28, 2016

This Funding Opportunity Announcement (FOA) solicits innovative and collaborative research focused on understanding the structure and function of proteins or protein complexes regulated by different AD genetic variants that have been identified to be associated with the sporadic and late onset Alzheimer’s disease (AD).  Specifically, NIA is interested in identifying and developing more effective and integrated platforms to screen protein functions, protein-protein interaction, protein complexes and their regulation by AD genetic variants prior to any in-depth mechanistic studies. The program encourages collaborative research projects that will translate initial GWAS discovery into functional and phenotypical insights and ultimately lead to understand the complex biology of AD.

 

RFA-AG-17-011: From Association to Function in the Alzheimer’s Disease Post Genomics Era (R21)

Expiration Date: September 28, 2016

This Funding Opportunity Announcement (FOA) solicits early stage innovative and exploratory research focused on understanding the structure and function of proteins or protein complexes regulated by different AD genetic variants that have been identified to be associated with the sporadic and late onset Alzheimer’s disease (AD).  This FOA is interested in identifying and developing novel and effective platforms to screen protein functions, protein-protein interaction, protein complexes and their regulation by AD genetic variants.

 

PAR-16-205: The National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family Based Study (FBS) (U24) 

Expiration Date: September 8, 2019

This Funding Opportunity Announcement (FOA) invites applications specific to infrastructure to support the Alzheimer's Disease Sequencing Project (ADSP) related to the collection, longitudinal follow-up, ascertainment of antecedent risk factors, and the characterization of additional relatives from families multiply affected with Alzheimer's disease (AD) in order to expand the existing NIA Late Onset of AD Family Based Study sample set.