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Alzheimer's Disease Sequencing Project

The overarching goals of the ADSP are to:

  • Identify new genomic variants contributing to increased risk of developing Late-Onset Alzheimer's Disease (LOAD)
  • Identify new genomic variants contributing to protection against developing Alzheimer's Disease (AD)
  • Provide insight as to why individuals with known risk factor variants escape from developing AD
  • Examine these factors in multi-ethnic populations as applicable in order to identify new pathways for disease prevention

The ADSP is comprised of five independent groups at 8 medical centers: see the NIH Press Release and the Memorandum of Understanding (MOU) for more information.

Two large, independent genetic consortia provide DNA and phenotypes:

Three NHGRI-funded Large-Scale Genome Sequencing and Analysis Centers (LSACs) provide in-kind sequencing and data processing support:

The ADSP is supported by the National Institute on Aging and the National Human Genome Research Institute. The NIA Genetics of Alzheimer's Disease Storage Site (NIAGADS) at the University of Pennsylvania acts as a coordinating center for the ADSP Discovery Phase.  Sample plating and shipping is coordinated by the National Cell Repository for Alzheimer’s Disease (NCRAD).  A list of the participating studies contributing samples to this project can be found here

Members of the ADSP participate in several working groups, each with monthly, bi-monthly, or weekly scheduled conference calls.

Qualified Principal Investigators (PIs) may submit applications for ADSP data through the dbGaP ADSP study page: phs000572.

For questions about the ADSP or its application process, contact ADSP administrative staff at adsp-help@niagads.org.