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Investigators

GCAD Principal Investigators

Gerard Schellenberg, PhD
Director, Penn Neurodegeneration Genomics Center
Professor, Pathology & Laboratory Medicine 

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Genetics and genomics of Alzheimer’s Disease and related dementia.

 

Li-San Wang, PhD
Co-Director, Penn Neurodegeneration Genomics Center
Associate Professor, Pathology & Laboratory Medicine 

Lab website / Personal website
Genetics of Alzheimer’s Disease and Related Dementia; computational methods for big data in genomics research.

 

GCAD Investigators 

Sandra Barral Rodrigues, PhD
Assistant Professor of Neurogenetics.

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Mapping genes contributing to the susceptibility for Alzheimer disease and other human neurodegenerative disorders.

 

Gary Beecham, PhD
Director, Division of Research Informatics in the Center for Genetic Epidemiology and Statistical Genetics, John P. Hussman Institute for Human Genomics

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Imputation methods, copy number analysis, and multiple testing problems.

 

William S. Bush, PhD
Assistant Professor, Epidemiology and Biostatistics

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Understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

 

Lindsay Farrer, PhD
Professor of Medicine, Neurology, Ophthalmology, Genetics & Genomics, Epidemiology, & Biostatistics Chief, Genetics Program

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Alzheimer disease (AD), Wilson disease, Machado-Joseph disease, Waardenburg .

 

Tatiana Foroud, PhD
Department Chair
Joe C. Christian Professor of Medical and Molecular Genetics
Chancellor's Professor, IUPUI
Director, Division of Hereditary Genomics

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Parkinson disease, Alzheimer disease, intracranial aneurysms, alcohol dependence, and cancer.

 

Jonathan L. Haines, PhD
Professor of Genomic Sciences
Chair, Department of Epidemiology and Biostatistics
Director, Institute for Computational Biology Case Western Reserve University School of Medicine

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Adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease.

 

Gyungah Jun
Director and Head, Neurogenetics and Integrated Genomics
Integrated Human Genomics (IHGx), CCLO-PCHQ, Eisai, Inc.
Adjunct Assistant Professor of Medicine, Boston University School of Medicine
Adjunct Assistant Professor, Dept of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University

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Statistical genetics, Genetic Epidemiology, Develop large consortium database, Develop software, Neurology and Ophthalmology.

 

Kathryn L Lunetta, PhD
Professor, Biostatistics

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Statistical problems and study design and analysis issues in human genetics, particularly in the mapping of complex genetic diseases. Collaborates as a statistical geneticist on several projects studying the genetic components of complex traits such as Huntington Disease, cardiovascular disease, and successful aging/longevity.

 

Jennifer J. Manly, PhD
Associate Professor, Neuropsychology in Neurology

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Health disparities in dementia, and cultural and educational influences on the epidemiology, biomarkers and neuropsychology of Alzheimer's disease.

 

Eden R. Martin, PhD
Director, The Center for Genetic Epidemiology and Statistical Genetics, John P. Hussman Institute for Human Genomics
Professor, Department of Public Health Sciences
Professor, Dr. John T. Macdonald Foundation Department of Human Genetics

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Mapping genes in complex diseases (Alzheimers, Parkinsons, autism), statistical methods, DNA sequence data, genetics of Latin American populations. 

 

Richard P. Mayeux, MD, MSc 
Chair, Department of Neurology
Director, Gertrude H. Sergievsky Center
Co-Director, Taub Institute for Research on Alzheimer's Disease and the Aging Brain
Director, Human Genetic Resources Core

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Alzheimer's Disease, Dementia, Aging, Epidemiology, Genetic Disorders.

 

Adam Naj, PhD
Assistant Professor of Epidemiology in Biostatistics and Epidemiology 

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Genetic epidemiology for Alzheimer’s disease (AD) and other neurodegenerative diseases.

 

Margaret Pericak-Vance, PhD
Director, John P. Hussman Institute for Human Genomics
Dr. John T. Macdonald Foundation Professor of Human Genetics
Executive Vice Chair, Dr. John T. Macdonald Foundation Department of Human Genetics

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Neurogenetic diseases such as Alzheimer disease, amyotrophic lateral sclerosis and multiple sclerosis, and has several active studies in neurodevelopmental disorders, such as autism and Asperger disorder.

 

Christiane Reitz, MD, PhD
Assistant Professor of Neurology and Epidemiology (in the Gertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain)

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Identification of genetic and non-genetic factors that contribute to Alzheimer's disease, frontotemporal lobar degeneration, and structural and functional brain changes.

 

Badri N. Vardarajan, PhD, MS
Assistant Professor of Bioinformatics in Neurology and the Gertrude H. Sergievsky Center

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Cell Biology, Neuroscience, Genetics, Cell, Protein Expression, R, Genomics, Science, and Computational Biology.

 

Nancy Zhang, PhD 
Associate Professor of Statistics 

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Change-point methods, empirical bayes estimation, genomics., model and variable selection, scan statistics, statistical modeling.